RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-424
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; etc.
Target
SMURF2
Pathway
NA
PubMed ID
Title
Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition
Year
2014
Function
"Micrornas chips and real-time PCR confirmed in A549 EMT model has six, three cut micrornas, the expression level of miR - 424 through targeted Smurf2 enhance TGF - beta signaling pathways regulating muscle into fiber cell differentiation 6 up-regulated and 3 down-regulated miRNAs in a human lung epithelial cell EMT model were validated using miRNA microarray and real-time PCR. Up-regulated miR-424 regulates the myofibroblast differentiation during EMT by potentiating the TGF-B signaling pathway through Smurf2."